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Nasrin suffered a number of physical and other attacks for her critical scrutiny of Islam and her demand for women's equality. Hundreds of thousands fanatics took to the streets demanding her execution by hanging. In October , a radical fundamentalist group called the Council of Islamic Soldiers offered a bounty for her death.
A few hundred thousand demonstrators called her "an apostate appointed by imperial forces to vilify Islam"; a member of a "militant faction threatened to set loose thousands of poisonous snakes in the capital unless she was executed. She returned to the East and relocated to Kolkata, India, in , where she lived until After she was physically attacked by Muslim fanatics in Hyderabad, she was forced to live under house arrest in Kolkata and finally she was thrown out of West Bengal in 22 November She was then forced to live under house arrest in Delhi for 3 months.
She had no other alternative but to leave India in She was not allowed to live in India for a while, but ultimately Nasrin, determined to live in the subcontinent moved to India from USA. Her Bangladeshi passport had been revoked; she was granted citizenship by the Swedish government and took refuge in Germany. In she wrote Meyebela, My Bengali Girlhood her biographical account from birth to adolescence.
She never got a Bangladeshi passport to return to the country when her mother,  and later her father,[ citation needed ] were on their death beds. In March , she visited Mumbai to promote a translation of her novel Shodh translated by Marathi author Ashok Shahane, the book was called Phitam Phat. Secular "atheist" groups seized upon the occasion to celebrate freedom of expression, while "radical fundamentalist groups While living in Kolkata, Nasrin regularly contributed to Indian newspapers and magazines, including Anandabazar Patrika and Desh , and, for some time, wrote a weekly column in the Bengali version of The Statesman.
Eurycoma longifolia Eurycoma longifolia Jack Simaroubaceace , known locally as Tongkat Ali, is commonly found in lowland forests. It is very commonly used by ethnic groups for numerous reasons and is one of the major export components from Malaysia [ 63 ]. An electric grid was used as an obstruction in the electrical copulation cage in order to determine how much an aversive stimulus the sexually naive male rat for both the treated with E.
The intensity of the grid current was maintained at 0. Results showed that E. Ethanol extract treatment for 10 days increased the sexual performance of the treated male rats by extending the duration of coitus and decreasing the refractory period between the different series of copulation [ 65 ]. Butanol, methanol, water, and chloroform extracts of the roots of E. Lepidium meyenii Lepidum meyenii Walp Brassicaceae known as Maca is the edible root traditionally employed for its purported aphrodisiac and fertility-enhancing properties.
Subacute oral administration of hexanic, methanolic, and chloroform extracts of Maca Lepidium meyenii root significantly decreased intromission latency and intercopulatory interval and increased intromission frequency and copulatory efficacy as compared to controls.
Hexanic and methanolic extracts were able to increase mount frequency, while only hexanic fraction significantly improved mount latency. Globally, only the hexanic fraction significantly improved the majority of the sexual parameters measured.
Subacute oral administration of hexanic Maca extract improved sexual performance parameters in sexually inexperienced male rats most effectively [ 71 ]. Oral administration of lipidic extract from Lepidium meyenii enhanced the sexual function of the mice and rats, as evidenced by an increase in the number of complete intromissions and the number of sperm-positive females in normal mice, and a decrease in the latent period of erection in male rats with erectile dysfunction [ 72 ].
Improvement of larginine-nitric oxide activity has also been attributed to Maca. The acute and daily administration of Maca in sexually experienced male rats produced a small change in ejaculation latency and postejaculatory interval and these changes disappeared with chronic treatment. Chronic administration of Maca did not increase anxiety and had some effect on locomotor activity [ 73 ].
Black maca appeared to have more beneficial effects on sperm counts and epididymal sperm motility after 42 days of treatment [ 74 ]. Maca has also shown effectiveness as a lead treatment for the dysfunction arising due to metalic lead exposure. Maca protects spermatogenesis by increasing lengths of stages VIII and IX—XI and daily sperm count that result in an increase in epididymal sperm number [ 75 ].
Oral treatment with ethyl acetate fraction of the hydroalcoholic extract of Black Maca for 7 days had the most beneficial effect on epididymal sperm count and daily sperm count compared with other fractions [ 76 ].
Maca enhanced fertility in both men and women [ 77 , 78 ]. Improvement of sexual desire is not related to changes in pituitary or gonadal hormones [ 79 , 80 ]. Maca does not activate androgen receptors and may actually block androgen receptors [ 81 , 82 ]. The effect on reproductive physiology may be observed at 0.
Mucuna pruriens Mucuna pruriens Linn. Family Leguminosae is a popular Indian medicinal plant, which has long been used in traditional Ayurvedic Indian medicine. The total alkaloids from the seeds of M. The ethanolic extracts of M.
There is significantly increased mounting frequency, intromission frequency, and ejaculation latency and decreased mounting latency, intromission latency, postejaculatory interval, and interintromission interval [ 87 ]. The recovery is mediated by reduction in ROS level, restoration of MMP, regulation of apoptosis, and eventual increase in the number of germ cells and regulation of apoptosis. Administered of seed extract of M. The Treatment with M. After the treatment of extract the seminal plasma of all the infertile groups, the levels of lipids, antioxidant vitamins, and corrected fructose were recovered after a decrease in lipid peroxides after treatment Their was recovered sperm concentration significantly in oligo-zoospermic patients, but sperm motility was not restored to normal levels in astheno-zoospermic men [ 90 ].
It also significantly recovered sperm count and motility. Treatment with M. It reactivates the antioxidant defense system of infertile men and also helps in the management of stress and improves semen quality [ 94 ].
Tribulus terrestris The plant Tribulus terrestris Linn. Zygophyllaceae popularly known as puncture vine is a perennial creeping herb with a worldwide distribution. Since ancient times it is regarded as an aphrodisiac in addition to its beneficial claims on various ailments such as urinary infections, inflammations, leucorrhoea, oedema, and ascites [ 95 ].
Administration of T. It also found to increase the levels of testosterone, luteinizing hormone [ 97 ], dehydroepiandrosterone, dihydrotestosterone, and dehydroepiandrosterone sulphate [ 98 , 99 ]. The corpus cavernosal tissues obtained from New Zealand white rabbits following treatment with T. Treatment of castrated rats with T. There was an improvement of the sexual behaviour parameters as evidenced by increase in mount frequency and intromission frequency; decrease in mount latency, intromission latency, and penile erection index [ , ].
Androgens are known to increase both androgen receptor and NADPH-d positive neurons either directly or by its conversion to oestrogen.
The mechanism for the observed increase in AR and NADPH-d positive neurons in the present study is probably due to the androgen increasing property of T. Such increase in androgen levels could be the responsible factor for the age-old claims of PTN as an aphrodisiac and therefore T. The ability of tribulus to increase the release of nitric oxide may account for its claims as an aphrodisiac [ , ].
Withania somnifera Ashwagandha Withania somnifera L. Dunal, Family: Solanaceae is also known as Indian ginseng commonly used in Ayurvedic medicine. It is best regarded as adaptogen, tonic with aphrodisiac properties. Some workers have reported the decrease mating behavior and antifertility effects of W. The root extract induced a marked impairment in libido, sexual performance, sexual vigour, and penile erectile dysfunction [ ].
It also showed antifertility activity in male rat [ ]. But some scientist shows that W. It also protects swimming-induced reproductive endocrine dysfunctions in male rat [ ]. Aqueous extract improved spermatogenesis, which may be due to increased interstitial cell stimulating hormone and testosterone-like effects as well as the induction of nitric oxide synthase [ ].
Ashwagandha root extract administered to the oligospermic patients resulted in a significantly greater improvement in spermatogenic activity and serum hormone levels as compared to the placebo treated [ ]. Treatment of infertile men with Withania somnifera inhibited lipid peroxidation and protein carbonyl content and improved sperm count and motility. It also recovered the seminal plasma levels of antioxidant enzymes W. Conclusion Various herbs have been used by people of different cultures to treat conditions of male infertility or for treatment of reproductive disorders.
They have also been advocated for improving sexual desire as well as sexual performance and erectile dysfunction, vasodilatation, increased testosterone level, brain monoamines, effect on pituitary-gonadal axis, and so forth are suggested mechanism for its action of these herbs [ ]. In absence of clinical efficacy and safety data on these herbs, people are skeptical to use them. There is an urgent need to conduct clinical studies to support traditional claims and to work out cellular and molecular mechanism involved.
Investigations in validation of the herbs will go a long way in management of infertility. Moreover, the cross talk of various pathways involved must also be taken into account to come up with a molecular pathway to find a lead molecule of herbal origin of the treatment of various forms of sexual dysfunction. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.
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